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Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a bitter taste. It is very slightly soluble in water and soluble in methanol, ethanol, chloroform, and acetone. Chemically, it is (αS,1R)-α-[2-(Dimethylamino)-1-methylethyl]-αphenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate, which can be represented by the accompanying structural formula. Its molecular weight is 565.74.

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Dosage and Administration

DARVOCET-N 100 (100 mg propoxyphene napsylate and 650 mg acetaminophen) the usual dosage is one tablet every 4 hours orally as needed for pain. The maximum dose of DARVOCET-N 100 is 6 tablets per day. Do not exceed the maximum daily dose. DARVOCET-N 50 (50mg propoxyphene napsylate and 325 mg acetaminophen) the usual dosage is two tablets every 4 hours orally as needed for pain. The maximum dose of DARVOCET-N 50 is 12 tablets per day. Do not exceed the maximum daily dose.


Darvocet may also be used for purposes not listed in this medication guide. Darvocet is used to relieve mild to moderate pain with or without fever. 

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction to Darvocet: hives; difficulty breathing;swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:shallow breathing, slow heartbeat, feeling like you might pass out;chest pain, feeling short of breath confusion, unusual thoughts or behavior seizure (convulsions) or nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).Less serious Darvocet side effects include:feeling dizzy or drowsymild nausea, vomiting, upset stomach, constipation;headache, blurred vision or dry mouth.

-Shallow breathing

-Slow heartbeat

-Feeling like you might pass out; chest pain,

-Feeling short of breath; confusion

-Unusual thoughts or behavior; seizure (convulsions);

-Or nausea, stomach pain, loss of appetite


There have been numerous cases of accidental and intentional overdose with propoxyphene products either alone or in combination with other CNS depressants, including alcohol. Fatalities within the first hour of over dosage are not uncommon. Many of the propoxyphene related deaths have occurred in patients with previous histories of emotional disturbances or suicidal ideation/attempts and/or concomitant administration of sedatives, tranquilizers, muscle relaxants, antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene for patients who are suicidal or have a history of suicidal ideation. For more info: Wiki


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