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The maximum dose should not exceed 400 mg per day. Normal-release forms may be given every 4-6 hours and the extended-release forms should be given every 12-24 hours. To minimise adverse effects at the start of the therapy and to improve tolerability, a 10-day or 16-day titration schedule of tramadol (immediate-release) is recommended.27 Extended-release preparations are better tolerated and are dosed once or twice daily. Tramadol is marketed as the hydrochloride salt and is available in a variety of pharmaceutical formulations for oral (tablets, capsules), sublingual (drops), intranasal, rectal (suppositories), intravenous, subcutaneous, and intramuscular administration. It is also available in combination with acetaminophen (paracetamol). Immediate-release and extended-release formulations are available. The following pharmaceutical formulations are available for oral use: – 50 mg immediate-release tablets/capsules – 50 mg; 100 mg; 150 mg; 200 mg; and 300 mg extended-release tablets/capsules – 37.5 mg tramadol + 325 mg acetaminophen tablets/capsules The recommended daily dose is in the range of 100-400 mg.
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help relieve moderate to moderately severe pain. Tramadol is similar to opioid(narcotic) analgesics.
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Seizures have been reported in patients receiving ULTRAM within the recommended dosage range. Spontaneous post-marketing reports indicate that seizure risk is increased with doses of ULTRAM above the recommended range. Co ncomitant use of ULTRAM increases the seizure risk in patients taking: Selective serotonin re-uptake inhibitors (SSRI antidepressants or anorectics), Tricyclic antidepressants (TCAs), and other tricyclic compounds (e.g., cyclobenzaprine , promethazine, etc.), or 7 Other opioids. Wikipedia