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Dosage and Administration
Children: Because of varied responses, initiate therapy with lowest dose and increase as required. Not for use in children under six months. See CONTRAINDICATIONS. The initial dose should be between 1 mg and 2.5 mg, three or four times daily initially; increase gradually as needed and tolerated.
Adults: Symptomatic relief of anxiety and tension in psychoneurosis and anxiety reactions: Depending upon severity of symptoms, the initial dose should be between 2 mg and 10 mg, two to four times daily.
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Used to treat anxiety, alcohol withdrawal, and seizures.
fatigue, drowsiness, muscle weakness and ataxia; they are usually dose-related. These adverse events occur predominantly at the start of therapy and usually disappear with prolonged administration
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Valium is not recommended in the treatment of psychotic patients and should not be employed instead of appropriate treatment. Since Valium has a central nervous system depressant effect, patients should be advised against the simultaneous ingestion of alcohol and other CNS depressant drugs during Valium therapy. As with other agents that have anticonvulsant activity, when Valium is used as an adjunct in treating convulsive disorders, the possibility of an increase in the frequency and/or severity of grand mal seizures may require an increase in the dosage of standard anticonvulsant medication. Abrupt withdrawal of Valium in such cases may also be associated with a temporary increase in the frequency and/or severity of seizures.
Valium is contraindicated in patients with a known hypersensitivity to diazepam and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age. Valium is also contraindicated in patients with myasthenia gravis, severe respiratory insufficiency, severe hepatic 3 insufficiency, and sleep apnea syndrome. It may be used in patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow-angle glaucoma.
Adverse Drug Reaction Overview the most common adverse reactions reported for VALIUM (diazepam) is fatigue, drowsiness, muscle weakness and ataxia; they are usually dose-related. These adverse events occur predominantly at the start of therapy and usually disappear with prolonged administration. Serious and Important Adverse Reactions the more serious adverse reactions occasionally reported are leucopenia, jaundice and hypersensitivity. Because of isolated reports of neutropenia and jaundice, periodic blood counts and liver· function tests are recommended during long term therapy. Allergic reactions and a very few cases of anaphylaxis have been reported to occur with· benzodiazepines. There have been reports of falls and fractures in benzodiazepine users. The risk is increased in those taking concomitant sedatives (including alcoholic beverages) and in the elderly. Anterograde amnesia may occur with therapeutic dosages of benzodiazepines, the risk increasing at higher dosages. Effects of anterograde amnesia may be associated with inappropriate behavior. Wikipedia